On 4 December 2025, the CRG/UPF Proteomics Unit, node of the Unique Science and Technology Infrastructure Omicstech, based at the Centre for Genomic Regulation (CRG), and the Catalan Society of Biology (SCB) hosted the Annual Proteomics Symposium 2025 — a premier gathering of scientists and experts dedicated to advancing proteomics for biomedical and life-science research.

At the heart of the symposium was the exploration of how the proteome responds to cellular perturbations through spatial redistribution, and to delve into protein interaction dynamics, protein structures and advanced computational proteomics.  The program featured world-class invited speakers including Julia Chamot-Rooke (Institut Pasteur), Kathryn Lilley (University of Cambridge), Alberto Santos (Danmarks Tekniske Universitet), and Mathias Wilhelm (Technische Universität München), as well as several early-career researchers from CRG and other affiliated institutions.

Sessions covered a broad spectrum of topics: computational proteomics, RNA–protein interactions, structural interactomics, mass-spectrometry innovations, and applications to disease models and clinical biomarker discovery. A key focus was on how perturbations at the cellular level — environmental, genetic or pharmacological — reshape the proteome, influencing not only protein expression but spatial distribution and interaction networks.

A standout feature this year was the inclusion of short-talk and poster opportunities for early-career researchers, encouraging the exchange of fresh ideas and data. As always, the symposium served not only as a forum to present results, but as a space to foster collaboration across laboratories, disciplines, and national borders. 

By bringing together leading minds in mass spectrometry, bioinformatics, structural biology, and clinical research, the Symposium reaffirmed CRG’s commitment to pushing the boundaries of proteomics — making complex biological systems more accessible and translational, from fundamental research to real-world applications.

Mark your calendars for the 2026 edition on Nov 6 — where new discoveries, new methods and new collaborations will continue to shape the future of proteomics.